A new synthetic route of 571188-59-5

Statistics shows that 571188-59-5 is playing an increasingly important role. we look forward to future research findings about tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate.

571188-59-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, the common compound, a new synthetic route is introduced below.

In the nitrogen atmosphere, the 6-acetyl-8-cyclopentyl-5-methyl-2-chlorine-pyrido[2,3-d]pyrimidin-7(8H)-one (VI) (1.53 g, 5 mmol), 4-(6-amino-3-pyridinyl)-1- piperazinecarboxylic acid 1,1-dimethylethyl ester (VII) (2.78 g, 10 mmol), Lithium bis(trimethylsilyl)amide (2.0 g, 10 mmol) and methylbenzene of 50 mL were added into the reaction bulb. They were heated up to 50-55 C. and react for 2-3 hours, and then cooled down to the room temperature after the completion of TLC detection reaction. The organic layer was separated out by pouring the reaction mixture into icy water, extraction was conducted for the water layer with methylbenzene for two times, and organic phases were combined. The organic layer was washed with water and saline solution respectively, and dried and concentrated to dry with anhydrous sodium sulfate. The residues obtained were dissolved into the dichloromethane of 50 mL, which was added with the concentrated hydrochloric acid of 5 mL and stirred in the room temperature for 12 hours. The organic phase was separated out and washed with water and solution of 10% sodium bicarbonate. The solvent was recycled under normal pressure and added with diethyl ether to separate solids. The crude products obtained were recrystallized with normal hexane and ethyl acetate, and off-white solid Palbociclib (I) of 1.85 g was obtained; yield: 82.6%; mass spectrometry (EI): m/z 448(M+H).

Statistics shows that 571188-59-5 is playing an increasingly important role. we look forward to future research findings about tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate.

Reference:
Patent; SUZHOU MIRACPHARMA TECHNOLOGY CO., LTD.; XU, Xuenong; (8 pag.)US2017/247380; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem