New downstream synthetic route of 1122-54-9

Statistics shows that 1122-54-9 is playing an increasingly important role. we look forward to future research findings about 4-Acetylpyridine.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1122-54-9, name is 4-Acetylpyridine. This compound has unique chemical properties. The synthetic route is as follows. 1122-54-9

[00234] To a solution of l-(pyridin-4-yl)ethanone (1.0 g, 8.25 mmol) in HOAc (60 mL) under ice bath was added aqueous HBr (1 mL, 48%) and Br2 (1.45 g, 9.1 mmol) in HOAc (20 mL). The mixture was stirred at rt for 4 h during which time a precipitate formed. Filtration of the solid provided 2-bromo-l-(pyridin-4-yl)ethanone hydrobromide (0.72 g, 3.6 mmol) as a yellow solid. LC/MS [M+H]+ = 200.1.

Statistics shows that 1122-54-9 is playing an increasingly important role. we look forward to future research findings about 4-Acetylpyridine.

Reference:
Patent; SUNOVION PHARMACEUTICALS INC.; NEWCOM, Jason, S.; SPEAR, Kerry, L.; WO2015/88564; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem