115473-15-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115473-15-9, name is 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.
The temperature was controlled at 10 to 15 C, 3000 ml of acetonitrile was added to the reaction flask, and 428 g (2.23 mol) of5,6,7,7a-tetrahydrothiophene [3,2-c] 2-pyridone hydrochloride, 1180 g of potassium hydrogencarbonate was slowly added, and then 488 g (2.05 mol) of intermediate 1 was mixed with 400 ml of acetonitrile The reaction mixture was stirred for 18-20 hours. The reaction was monitored by TLC. The solid was filtered off and the solid was removed. The filtrate was concentrated under reduced pressure to distill off the solvent. To the residue was added 1500 ml of ethyl acetate and 1500 ml of n-hexane And the mixture was stirred at 50-60 C for 2 hours. The mixture was filtered through hot filtration and the solid was discarded. The solvent was distilled off from the filtrate under reduced pressure. The residue was dissolved in 1500 ml of acetone, cooled to 5-10 C, and 40% hydrobromic acid 337 ml, The reaction mixture was stirred at 20-25 C for 3 h, cooled to 0-5 C, filtered and rinsed with 200 ml of acetone and dried in vacuo at 40 C for 2 h to give intermediate 2 (5- (alpha-cyclopropylcarbonyl -benzyl) -2-oxo-2,4,5,6,7,7a-hexahydrothieno (3,2-c) pyridine) in about 423 g, 45-60%
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 115473-15-9, 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride.
Reference:
Patent; Beijing Pharmaceutical Technology Development Co., Ltd.; li, jiao; zhao, bo; zhang, lei; (9 pag.)CN105503900; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem