Analyzing the synthesis route of 16013-85-7

With the rapid development of chemical substances, we look forward to future research findings about 16013-85-7.

A common compound: 16013-85-7, name is 2,6-Dichloro-3-nitropyridine,molecular formula is C5H2Cl2N2O2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 16013-85-7

At room temperature2,6-dichloro-3-nitropyridine (2.50 g) of N-methylpyrrolidone (25 mL) Copper cyanide (1) (2.32 g), and stirred at 180 C for 1 hour.After the reaction mixture was cooled to room temperature, ethyl acetate and water were added, and the mixture was filtered through celite. The filtrate was washed with saturated brine, and the aqueous layer was re-extracted with ethyl acetate. The combined organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and distilled under reduced pressure to remove the organic layer. The obtained crude product was purified by silica gel column chromatography (elution solvent: n-hexane / ethyl acetate = 90/10 to 70/30) to obtain the title compound (0.90 g).

With the rapid development of chemical substances, we look forward to future research findings about 16013-85-7.

Reference:
Patent; KISSEI PHARMACEUTICAL CO., LTD.; SHIMIZU, KAZUO; MIYAGI, TAKASHI; OHNO, KOHSUKE; UENO, YASUNORI; ONDA, YUSUKE; SUZUKI, HIKARU; (70 pag.)TW2016/5823; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem