571188-59-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.
1) Replace the reaction flask three times with inert gas N2,Add 1140g of toluene to the reaction flask.Then, 93 g of 4-(6-aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester was added.Cool down to 20 C,Add 140g of isopropylmagnesium chloride,After the addition is completed within 1 hour,Activated for 30 minutes;Continue to add 95 g of 6-bromo-2-chloro-8-cyclopentyl-5-methyl-pyrido[2,3-D]pyrimidin-7(8H)-one, and complete the addition within 1 hour;Continue to add 140g of isopropylmagnesium chloride,After the addition is completed within 1 hour,The temperature was raised to 60 C for 30 minutes.Until the end of the reaction,By adding dropwise a mixture of acetic acid/tetrahydrofuran (mass ratio of acetic acid to tetrahydrofuran: 1:10), the pH of the solution was adjusted to precipitate a solid, and the temperature was lowered to 0 C, filtered, and the filter cake was dried to obtain a yellow solid powder intermediate I141 g, yield 87%. . The HPLC chromatogram of the obtained Pabsini intermediate I is shown in Fig. 2. As can be seen from Fig. 2, the purity of the intermediate I is99.45%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 571188-59-5, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate.
Reference:
Patent; Chongqing San Sheng Industrial Co., Ltd.; Wen Jiandong; Peng Lei; He Wei; Yang Zhikun; Fan Jun; Yang Huan; (11 pag.)CN109336886; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem