Adding a certain compound to certain chemical reactions, such as: 109-04-6, 2-Bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 109-04-6, blongs to pyridine-derivatives compound. 109-04-6
Example 32; 2-tributylstannylpyridine (18); Butyllithium (2.5 M in hexane, 6.33 mmol) is added to a solution of 2-bromopyridine (1 g, 6.33 mmol) in THF (12 mL) freshly distilled and degassed at -78 C. The reddish solution is stirred for 30 minutes at -78 C. Tributyltin chloride (1.7 mL, 6.33 mmol) is then added and the solution is stirred for 1 hour -78 C. and for 1 hour at room temperature. The mixture is treated with a NH4Cl saturated solution and extracted with diethylic ether. The organic phase is washed with a NaCl saturated solution, dried over MgSO4 and concentrated under reduced pressure. The residue is submitted to aluminium column chromatography (hexane/AcOET: 20/1), thus providing a pure product with a yield of 94%.1H RMN (CDCl3) delta (ppm): 8.73 (ddd, J=4.9, 1.9, 1.0, 1H, H6), 7.48 (dt, J=7.4, 1.8, 1H, H5), 7.39 (dt, J=7.4, 1.6, 1H, H3), 7.10 (ddd, J=6.9, 4.9, 1.7, 1H, H4), 1.70-1.05 (m, 18H, CH2), 0.85 (t, 9H, J=7.3, CH3).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-04-6, its application will become more common.
Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.; US2010/4443; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem