Authors Abdelkafi, H; Michau, A; Pons, V; Ngadjeua, F; Clerget, A; Ouarab, LA; Buisson, DA; Montoir, D; Caramelle, L; Gillet, D; Barbier, J; Cintrat, JC in AMER CHEMICAL SOC published article about PROTECTS; TRAFFICKING; ENANTIOMERS; INHIBITION in [Abdelkafi, Hajer; Michau, Aurelien; Ngadjeua, Flora; Clerget, Alexandra; Caramelle, Lucie; Gillet, Daniel; Barbier, Julien] Univ Paris Saclay, Dept Medicaments & Technol Sante DMTS, SIMoS, CEA,INRAE, F-91191 Gif Sur Yvette, France; [Pons, Valerie; Ouarab, Lilia Ait; Buisson, David-Alexandre; Montoir, David; Cintrat, Jean-Christophe] Univ Paris Saclay, Dept Medicaments & Technol Sante DMTS, SCBM, CEA,INRAE, F-91191 Gif Sur Yvette, France in 2020.0, Cited 23.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1
High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. To improve the activity of Retro-1, a structure-activity relationship (SAR) study was undertaken and yielded an analogue with a roughly 70-fold better half-maximal effective concentration (EC50) against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem