5398-44-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5398-44-7, name is 2,6-Dichloroisonicotinic acid, molecular formula is C6H3Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2,6-Dichloroisonicotinic acid (10 g, 54.6 mmol), N,O-dimethylhydroxylaminehydrochloride (7.99 g, 81.89 mmol), HOBt(8.85 g, 65,52 mmol) and EDCI (12.56 g, 65.52 mmol) were dissolvedin DCM and Et3N (11.38 mL, 81.89 mmol) was added. Afterbeing stirred at room temperature overnight, the reaction mixturewas filtered and the solvent was evaporated in vacuo. The crudeproduct was purified by column chromatography with petroleum/ethyl acetate (4:1) to give intermediate 9 as a white solid (9.97 g,85.45%); 1H NMR (300 MHz, CDCl3) delta 7.50 (s, 2H), 3.58 (s, 3H), 3.37(s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5398-44-7, 2,6-Dichloroisonicotinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Shuai, Wen; Li, Xinnan; Li, Wenlong; Xu, Feijie; Lu, Lixue; Yao, Hong; Yang, Limei; Zhu, Huajian; Xu, Shengtao; Zhu, Zheying; Xu, Jinyi; European Journal of Medicinal Chemistry; vol. 197; (2020);,
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