In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 624-28-2, name is 2,5-Dibromopyridine, the common compound, a new synthetic route is introduced below. 624-28-2
To a solution of 2,5-dibromopyridine (10.50 g, 44 mmol) in 210 mL of pyridine was added hydrazine hydrate (80%, 8.85 g, 176.4 mmol), and the mixture was heated to 110 C. and stirred further for 2 hours, then cooled to rt, and concentrated in vacuo. The residue was diluted with DCM (1500 mL). The resulted mixture was washed with aqueous NaOH solution (1 M, 350 mL), dried over anhydrous Na2SO4, and concentrated in vacuo to give the title compound as a gray solid (7.87 g, 94.8%). MS (ESI, pos. ion) m/z: 188.0[M+H]+; 1H NMR (600 MHz, DMSO-d6): delta 8.03 (d, J=2.3 Hz, 1H), 7.67 (s, 1H), 7.59 (dd, J=8.9, 2.5 Hz, 1H), 6.69 (d, J=8.9 Hz, 1H), 4.16 (s, 2H).
Statistics shows that 624-28-2 is playing an increasingly important role. we look forward to future research findings about 2,5-Dibromopyridine.
Reference:
Patent; Calitor Sciences, LLC; Xi, Ning; US2014/134133; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem