The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. 69045-84-7
Into a 500 mL autoclave, 51.2 g (0.2348 mol, 99%, 1.0 eq) of 2,3-dichloro-5-trifluoromethylpyridine and 160 mL of tetrahydrofuran were placed, and the autoclave was closed.Nitrogen was replaced three times at normal temperature, and 20.0 g (1.174 mol, 5.0 eq) of liquid ammonia was passed through the system, and the pressure in the system was about 0.6 MPa.The temperature was raised to 100 C to maintain the pressure reaction for 28 h.The system pressure was reduced from 1.6Mpa to 1.2Mpa, and the reaction of the raw material in the bottom tube sampling HPLC was complete. After the system is lowered to normal temperature, the pressure is released to normal pressure.The ammonia gas released is absorbed by tetrahydrofuran.The reaction solution was taken out, filtered, and rinsed with an appropriate amount of tetrahydrofuran, and the mother liquid was subjected to the next step of deamination.
Statistics shows that 69045-84-7 is playing an increasingly important role. we look forward to future research findings about 2,3-Dichloro-5-(trifluoromethyl)pyridine.
Reference:
Patent; Dalian Jiu Xin Fine Chemical Co., Ltd.; Inner Mongolia Jiaruimi Fine Chemical Co., Ltd.; Wang Rongliang; Wang Junchun; (10 pag.)CN110143916; (2019); A;,
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