609-71-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid. A new synthetic method of this compound is introduced below.
1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (5). A stirred suspension of NaH 60% dispersion in mineral oil (206 mg, 5.14 mmol), washed twice with distilled n-hexane and once with Et20 under N2 atmosphere, was treated dropwise with a solution containing the 2-hydroxynicotinic acid (600 mg, 4.31 mmol) in 5 mL of anhydrous DMF. The mixture was left under stirring at rt for 2h and then 3,4-difluoro-benzylbromide (1 .06 g, 5.14 mmol) was added and the mixture stirred and heated at 50C for 1 6h. After, the mixture was concentrated under reduced pressure and the residue was treated with water to give a solid, which was collected by vacuum filtration. Next the solid was refluxed for 4h in aq. 10% NaOH (10 mL) and the resulting mixture was cooled and made acid with 1 N aq. HCI. The white solid formed was collected by filtration and washed with n-hexane and Et20, giving 5 as white solid (857 mg, 3.23 mmol, 75% yield). H-NMR (400 MHz, DMSO-de): delta 5.30 (s, 2H, CH2); 6.78 (t, 1 H, J = 6.9 Hz, Ar); 7.22-7.24 (m, 1 H, Ar); 7.41 -7.53 (m, 2H, Ar); 8.41 (d, 2H, J = 6.9 Hz, Ar) ppm. Anal. Calcd for C13H9NO3F2: C, 58.87%; H, 3.42%; N, (0126) 3%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 609-71-2, 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; INTERNATIONAL SOCIETY FOR DRUG DEVELOPMENT S.R.L.; SESTITO, Simona; DANIELE, Simona; MARTINI, Claudia; RAPPOSELLI, Simona; PURICELLI, Guido; (61 pag.)WO2017/211946; (2017); A1;,
Pyridine – Wikipedia,
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