Rong, MY; Yang, LJ; Nie, J; Zhang, FG; Ma, JA in [Rong, Meng-Yu; Yang, Lijun; Nie, Jing; Zhang, Fa-Guang; Ma, Jun-An] Tianjin Univ, Dept Chem, Tianjin Key Lab Mol Optoelect Sci, Tianjin 300072, Peoples R China; [Rong, Meng-Yu; Yang, Lijun; Nie, Jing; Zhang, Fa-Guang; Ma, Jun-An] Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China; [Ma, Jun-An] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China published Construction of Chiral beta-Trifluoromethyl Alcohols Enabled by Catalytic Enantioselective Aldol-Type Reaction of CF3CHN2 in 2019.0, Cited 53.0. Safety of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.
A zinc-/quinine-mediated enantioselective Aldol-type reaction of trifluorodiazoethane (CF3CHN2) with various aldehydes is described. This study demonstrated the feasibility of utilizing CF3CHN2 as an effective hard nucleophile in catalytic asymmetric transformations. Furthermore, the synthetic utility of this protocol is exemplified by the construction of a diverse set of chiral beta-trifluoromethylated alcohols, including a valuable HDAC inhibitor precursor.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem