Introduction of a new synthetic route about 23056-33-9

The chemical industry reduces the impact on the environment during synthesis 23056-33-9, I believe this compound will play a more active role in future production and life.

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 23056-33-9 as follows., 23056-33-9

Sodium metal (0.106g, 4.6mmol) was dissolved in methanol (5ml) at 0C, 2-chloro-4-methyl-5-nitro-pyridine (0.2g, 1.0mmol) was added and the reaction mixture stirred at 0C for 1 h and at room temperature for 1 h. The solvent was removed in vacuo, water (5ml) was added, the crystalline precipitate was filtered, washed with water and dried to give 0.13g (68%) of 2-methoxy-4-methyl-5-nitro-pyridine.

The chemical industry reduces the impact on the environment during synthesis 23056-33-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Phenex Pharmaceuticals AG; EP1894924; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem