The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. 609-71-2
Commercial available 2-hydroxynicotinic acid (1.5 ?g, 10.78? mmol) was dissolved in anhydrous DMF (20.0 ?mL) and then NaH (650.0 ?mg, 27.08 ?mmol) was slowly added. After 1?h?at room temperature, p-fluorobenzyl chloride (1.5 mL, 12.52?mmol) was added and the reaction mixture was heated under stirring at 50?C for 12?h. After cooling to room temperature, the reaction mixture was evaporated under reduced pressure affording a white solid that was treated with a solution of 10% NaOH (20.0? mL) and heated at reflux for 4?h. Then the mixture was cooled at room temperature and acidified with concentrated HCl until pH?=?1-2. The obtained solid was filtered under vacuum, washed with water and dried to afford pure compound 12 (2.6 ?g, yield: 96%). 1H NMR (400MHz, DMSO): delta 12.02 (bs, 1H, COOH), 8.42-8.47 (m, 2H, H4 and H6 Py) 7.22-7.50 (m, 4H, ArH), 6.83-6.80 (m, 1H, H5 Py), 5.34 (s, 2H, N-CH2).
Statistics shows that 609-71-2 is playing an increasingly important role. we look forward to future research findings about 2-Oxo-1,2-dihydropyridine-3-carboxylic acid.
Reference:
Article; Chicca, Andrea; Arena, Chiara; Bertini, Simone; Gado, Francesca; Ciaglia, Elena; Abate, Mario; Digiacomo, Maria; Lapillo, Margherita; Poli, Giulio; Bifulco, Maurizio; Macchia, Marco; Tuccinardi, Tiziano; Gertsch, Juerg; Manera, Clementina; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 155 – 171;,
Pyridine – Wikipedia,
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