4926-28-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4926-28-7, name is 2-Bromo-4-methylpyridine, molecular formula is C6H6BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 20; Synthesis of 2-bromoisonicotinic acid; [0119] 2-Bromo-4-methylpyridine (10 g, 0.058 moles) and potassium permanganate (18.3 g, 0.115 moles) was combined in water (500 ml). The mixture was refluxed for five hours, filtered through celite and reduced in volume to-400 ml. The dark brown solution was acidified with hydrochloric acid (10%) to pH-3. The resulting white precipitate was filtered and rinsed with ethyl ether. 2-Bromoisonicotinic acid was isolated in 34 % yield. 1H NMR (DMSO-d6) 7.8 (1H, d), 7.85 (1H, s), 8.5 (1H, d).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4926-28-7, 2-Bromo-4-methylpyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DOV PHARMACEUTICAL, INC.; WO2005/84439; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem