98-98-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 98-98-6, name is Picolinic acid, molecular formula is C6H5NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
5. Methyl 4-chloropicolinate; A mixture of picolinic acid (15 g, 122 mmol) sodium bromide (1.88 g, 18.3 mmol), and thionyl chloride (45 mL) is heated to reflux and stirred for 20 h. After cooling to rt, the excess thionyl chloride is removed in vacuo. The resulting residue is taken up in toluene (100 mL) and cooled to 0 0C. MeOH (7 mL) is added dropwise, after which time the reaction is warmed to rt and stirred an additional 1.5 h. The precipitated solid is collected by filtration, washed with toluene, and partitioned between EtOAc (200 mL) and water (100 mL). The mixture is neutralized to pH=7-8 with solid NaHCO3. The EtOAc layer is dried (Na2SO4), filtered, and evaporated in vacuo to give the title compound as a light brown solid. MS: 171.94 (M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 98-98-6, Picolinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NEUROGEN CORPORATION; WO2008/70014; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem