Why Are Children Getting Addicted To 500-22-1

SDS of cas: 500-22-1. Welcome to talk about 500-22-1, If you have any questions, you can contact Lozinskaya, NA; Babkov, DA; Zaryanova, EV; Bezsonova, EN; Borisov, AV; Tsymlyakov, MD; Anikina, LV; Zakharyascheva, OY; Borisov, AV; Perfilova, VN; Tyurenkov, IN; Proskurnina, MV; Spasov, AA or send Email.

In 2019.0 BIOORGAN MED CHEM published article about ALZHEIMERS-DISEASE; GSK-3 INHIBITORS; DESIGN; CANCER; GENE; COMBINATION; INDIRUBINS; METABOLISM; SIMULATION; EFFICIENT in [Lozinskaya, Natalia A.; Zaryanova, Ekaterina V.; Bezsonova, Elena N.; Borisov, Alexander V.; Tsymlyakov, Michael D.; Proskurnina, Marina V.] Lomonosov Moscow State Univ, Dept Chem, Leninskie Gory St 1, Moscow 119234, Russia; [Lozinskaya, Natalia A.; Anikina, Lada V.; Proskurnina, Marina V.] Russian Acad Sci, Inst Physiol Act Cpds, 1 Severnyi Proezd, Chernogolovka 142432, Russia; [Babkov, Denis A.; Zakharyascheva, Olga Yu.; Borisov, Alexander V.; Perfilova, Valentina N.; Tyurenkov, Ivan N.; Spasov, Alexander A.] Volgograd State Med Univ, Novorossiyskaya St 39, Volgograd 400087, Russia in 2019.0, Cited 49.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. SDS of cas: 500-22-1

Glycogen synthase kinase 3 beta (GSK-3 beta) is a widely investigated molecular target for numerous diseases including Alzheimer’s disease, cancer, and diabetes mellitus. Inhibition of GSK-3 beta activity has become an attractive approach for treatment of diabetes and cancer. We report the discovery of novel GSK-3 beta inhibitors of 3-arylidene-2-oxindole scaffold with promising activity. The most potent compound 3a inhibits GSK-3 beta with IC(50 )4.19 nM. In a cell-based assay 3a shows no significant leucocyte toxicity at 10 mu M and is moderately cytotoxic against A549 cells. Compound 3a demonstrated high antidiabetic efficacy in obese streptozotocin-treated rats improving glucose tolerance at a dose of 50 mg/kg body weight thus representing an interesting lead for further optimization.

SDS of cas: 500-22-1. Welcome to talk about 500-22-1, If you have any questions, you can contact Lozinskaya, NA; Babkov, DA; Zaryanova, EV; Bezsonova, EN; Borisov, AV; Tsymlyakov, MD; Anikina, LV; Zakharyascheva, OY; Borisov, AV; Perfilova, VN; Tyurenkov, IN; Proskurnina, MV; Spasov, AA or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem