An article Microwave-assisted synthesis and antibacterial propensity of N ‘-s-benzylidene-2-propylquinoline-4-carbohydrazide and N ‘-((s-1H-pyrrol-2-yl)methylene)-2-propylquinoline-4-carbohydrazide motifs WOS:000505076000135 published article about QUINOLINE DERIVATIVES; ESCHERICHIA-COLI; BINDING; MECHANISMS; RESISTANCE; DOCKING; OVENS in [Ajani, Olayinka O.; Iyaye, King T.; Aderohunmu, Damilola V.; Olanrewaju, Ifedolapo O.] Covenant Univ, Dept Chem, CST, Km 10 Idiroko Rd,PMB 1023, Ota, Ogun State, Nigeria; [Germann, Markus W.; Bello, Babatunde L.] Georgia State Univ, Dept Chem, Atlanta, GA 30302 USA; [Olorunshola, Shade J.] Covenant Univ, Dept Biol Sci, CST, Km 10 Idiroko Rd,PMB 1023, Ota, Ogun State, Nigeria in 2020.0, Cited 53.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. COA of Formula: C6H5NO
Microwave-assisted approach was utilized as green approach to access a series of 2-pro pylquinoline-4-carbohydrazide hydrazone derivatives 10a-j of aromatic and heteroaromatic aldehydes in highly encouraging yields. It involved four steps reaction which was initiated with ring opening reaction of isatin in a basified environment and subsequent cross-coupling with pentan-2-one to produce compound 7. Esterification of 7 in acid medium led to the formation of compound 8 which was reacted with hydrazine hydrate to access 9 which upon microwave-assisted condensed with aromatic and heteroaromatic aldehydes furnished the targeted compounds 10a-j. The structures of 10aj were confirmed by physico-chemical, elemental analyses and spectroscopic characterization which include UV, FT-IR, H-1 and C-13 NMR as well as DEPT-135. The targeted compounds 10a-j, alongside with gentamicin clinical standard, were investigated for their antibacterial efficacies using agar diffusion method. 2-Propyl-N’-(pyridine-3-ylmethylene) quinoline-4-carbohydrazide 10j emerged as the best antibacterial hydrazide-hydrazone with lowest MIC value of 0.39 +/- 0.02 – 1.56 +/- 0.02 mu g/ mL across all the organisms screened. (C) 2018 Production and hosting by Elsevier B.V. on behalf of King Saud University.
COA of Formula: C6H5NO. Welcome to talk about 500-22-1, If you have any questions, you can contact Ajani, OO; Iyaye, KT; Aderohunmu, DV; Olanrewaju, IO; Germann, MW; Olorunshola, SJ; Bello, BL or send Email.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem