Analyzing the synthesis route of 7379-35-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7379-35-3, 4-Chloropyridine hydrochloride, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7379-35-3, name is 4-Chloropyridine hydrochloride. A new synthetic method of this compound is introduced below., 7379-35-3

N-t-butoxycarbonyloxy 2- (piperidin-4-yl)-ethylamine (prepared per Method K’above) (14.4 g, 50 mmol), 4-chloropyridine HC1 (1.0 eq. , 8.0 g), TEA (2.2 eq. ) were mixed in ethanol, and maintained under reflux overnight. The desired compound, N-t-butoxycarbonyloxy 2- [1- (pyrid-4-yl) piperidin-4-yl] – ethylamine, was isolated by column chromato-graphy, (silica gel) eluted with EtOAc and carried in the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7379-35-3, 4-Chloropyridine hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2003/93245; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem