766-11-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 766-11-0, name is 5-Bromo-2-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a solution of alcohol 1a-r or benzyl mercaptan 1s (1.5 equiv.) in anhydrous THF (100 mL) was slowly added 60% sodium hydride (2.0 equiv.). The mixture was allowed to react at room temperature for 30 min then it was heated to reflux for 1 h. 5-bromo-2-fluoropyridine (1 equiv.) was added and the reaction was continued for 12 h. After cooling down to room temperature, the mixture was poured into water and extracted with ethyl acetate. The organic phase was washed with brine, dried on MgSO4, filtered, evaporated and purified by silica gel chromatography.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 766-11-0, 5-Bromo-2-fluoropyridine.
Reference:
Article; Fontaine, Fanny; Hequet, Arnaud; Voisin-Chiret, Anne-Sophie; Bouillon, Alexandre; Lesnard, Aurelien; Cresteil, Thierry; Jolivalt, Claude; Rault, Sylvain; European Journal of Medicinal Chemistry; vol. 95; (2015); p. 185 – 198;,
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