Category: pyridine-derivatives. Kyei-Baffour, K; Mohammad, H; Seleem, MN; Dai, MJ in [Kyei-Baffour, Kwaku; Dai, Mingji] Purdue Univ, Dept Chem, Ctr Canc Res, 720 Clinic Dr, W Lafayette, IN 47907 USA; [Kyei-Baffour, Kwaku; Dai, Mingji] Purdue Univ, Inst Drug Discovery, 720 Clinic Dr, W Lafayette, IN 47907 USA; [Mohammad, Haroon; Seleem, Mohamed N.] Purdue Univ, Dept Comparat Pathobiol, Coll Vet Med, 625 Harrison St, W Lafayette, IN 47907 USA; [Seleem, Mohamed N.; Dai, Mingji] Purdue Univ, Purdue Inst Inflammat Immunol & Infect Dis, 610 Purdue Mall, W Lafayette, IN 47907 USA published Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus in 2019.0, Cited 53.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.
Antibiotic resistance remains a major global public health threat that requires sustained discovery of novel antibacterial agents with unexploited scaffolds. Structure-activity relationship of the first-generation aryl isonitrile compounds we synthesized led to an initial lead molecule that informed the synthesis of a second-generation of aryl isonitriles. From this new series of 20 compounds, three analogues inhibited growth of methicillin-resistant Staphylococcus aureus (MRSA) (from 1 to 4 mu M) and were safe to human keratinocytes. Compound 19, with an additional isonitrile group exhibited improved activity against MRSA compared to the first-generation lead compound. This compound emerged as a candidate worthy of further investigation and further reinforced the importance of the isonitrile functionality in the compounds’ anti-MRSA activity. In a murine skin wound model, 19 significantly reduced the burden of MRSA, similar to the antibiotic fusidic acid. In summary, 19 was identified as a new lead aryl isonitrile compound effective against MRSA.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem