The common heterocyclic compound, 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 72830-09-2
General procedure: 2-Chloromethyl pyridine hydrochloride (0.8 g, 5.0 mmol), 2-chloromethyl-4-methoxy-3-methylpyridine hydrochloride (1.0 g, 5.0 mmol), 2-chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride (1.1 g, 5.0 mmol), 2-chloromethyl-3,4-dimethoxypyridine hydrochloride (1.12 g, 5.0 mmol), K2CO3 (1.1 g, 8.0 mmol) and KI (1.32 g, 8 mmol) were added to a magnetically stirred solution of 9 (1.24 g, 5.0 mmol) in a mixture of acetone (30 ml) and ethanol (30 ml). The reaction mixture was stirred constantly at 60 C for about 8 h. When the reaction was finished, as monitored by TLC, water (100 ml) was added. Then the reaction mixture was extracted with DCM (30 ml ¡Á 4). The organic phase was combined and concentrated under reduced pressure gave crude compounds 11a-d.
The synthetic route of 72830-09-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; El-Nezhawy, Ahmed O.H.; Biuomy, Ayman R.; Hassan, Fatma S.; Ismaiel, Ayman K.; Omar, Hany A.; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 1661 – 1670;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem