An article First heterobimetallic Cu(i)-dppf complexes designed for anticancer applications: synthesis, structural characterization and cytotoxicity WOS:000480521500012 published article about VITRO ANTITUMOR-ACTIVITY; COPPER(I) COMPLEXES; IN-VITRO; MOLECULAR-STRUCTURE; DNA-BINDING; CELL-LINE; FERROCENE; 1,1′-BIS(DIPHENYLPHOSPHINO)FERROCENE; LIGANDS; 1,2-BIS(DIPHENYLPHOSPHINO)ETHANE in [Bravo, Catarina; Sequeira, Diogo A.; Helena Garcia, M.; Villa de Brito, Maria J.; Morais, Tania S.] Univ Lisbon, Fac Ciencias, Ctr Quim Estrutural, Lisbon, Portugal; [Bravo, Catarina; Piedade, M. Fatima M.; Helena Garcia, M.; Villa de Brito, Maria J.; Morais, Tania S.] Univ Lisbon, Fac Ciencias, Dept Quim & Bioquim, Lisbon, Portugal; [Paula Robalo, M.; Piedade, M. Fatima M.] Univ Lisbon, Inst Super Tecn, Ctr Quim Estrutural, Lisbon, Portugal; [Paula Robalo, M.] Inst Politecn Lisboa, Inst Super Engn Lisboa, Area Dept Engn Quim, Rua Conselheiro Emidio Navarro 1, P-1959007 Lisbon, Portugal; [Marques, Fernanda] Univ Lisbon, Inst Super Tecn, Dept Engn & Ciencias Nucl, Ctr Ciencias & Tecnol Nucl, Lisbon, Portugal; [Fernandes, Alexandra R.; Sequeira, Diogo A.] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Ciencias Vida, UCBIO, Lisbon, Portugal in 2019.0, Cited 50.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. SDS of cas: 91-02-1
A new family of eight heterobimetallic Cu(i)-dppf complexes of general formula [Cu(dppf)L][BF4] with dppf = 1,1 ‘-bis(diphenylphosphino)ferrocene and L representing N,N-, N,O- and N,S-heteroaromatic bidentate ligands have been synthesized and fully characterized by classical analytical, spectroscopic and electrochemical methods. The single crystal structures of [Cu(dppf)(pBI)][BF4] (6), [Cu(dppf)(dpytz)][BF4] (7) and [Cu(dppf)(5-Aphen)][BF4] (8) complexes (where pBI = 2-(2-pyridyl)benzimidazole, dpytz = 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine and 5-Aphen = 1,10-phenanthrolin-5-amine) were determined by X-ray diffraction studies. Cytotoxicity of all complexes was evaluated in two human breast adenocarcinoma cell lines (MCF7 and MDAMB231). All the complexes exhibit high cytotoxicity against both human breast cancer cells with IC50 values far lower than those found for the antitumor drug cisplatin in the same cell lines. The IC50 values on primary healthy fibroblasts are of the same order of magnitude as those found for the tumoral cells.
SDS of cas: 91-02-1. Welcome to talk about 91-02-1, If you have any questions, you can contact Bravo, C; Robalo, MP; Marques, F; Fernandes, AR; Sequeira, DA; Piedade, MFM; Garcia, MH; de Brito, MJV; Morais, TS or send Email.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem