A new synthetic route of 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

With the rapid development of chemical substances, we look forward to future research findings about 888721-65-1.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 888721-65-1, name is 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 888721-65-1

To a solution of N- [6- (4-amino-3- fluorophenoxy) imidazo [1, 2-a] pyridin-2- yl] cyclopropanecarboxamide (150 mg, 0.46 mmol) in N, N- dimethylacetamide (3.0 mL) were added 1- (4-fluorophenyl) -6- methyl-2-oxo-l, 2-dihydropyridine-3-carboxylic acid (170 mg, 0.689 mmol), HATU (262 mg, 0.689 mmol) and N,N- diisopropylethylamine (120 muL, 0.689 mmol), and the mixture was stirred at room temperature for 20 hr. Saturated aqueous sodium hydrogen carbonate was added to the reaction mixture, and the mixture was extracted with ethyl acetate/tetrahydrofuran. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and filtered. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate and collected by filtration to give the title compound (208 mg, 81%) as a white solid. 1H-NMR (DMSO-d6, 300MHz) delta 0.77 – 0.81 (4H, m) , 1.86 – 1.96 (IH, m) , 2.07 (3H, s) , 6.70 (IH, d, J = 8.1 Hz), 6.86 – 6.92 (IH, m) , 7.06 – 7.12 (2H, m) , 7.40 – 7.52 (5H, m) , 8.04 (IH, s), 8.37 – 8.56 (3H, m) , 10.97 (IH, s) , 12.04 (IH, s) .

With the rapid development of chemical substances, we look forward to future research findings about 888721-65-1.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2009/136663; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem