Application of 1008-91-9, Adding some certain compound to certain chemical reactions, such as: 1008-91-9, name is 1-(Pyridin-4-yl)piperazine,molecular formula is C9H13N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1008-91-9.
General procedure: 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HATU; 1.2 equivalents) was added to a solution of the corresponding alpha-methyl carboxylic acid (2) (1 equiv), the appropriate amine (1.5 equiv) and DIEA (2 equiv) in dry acetonitrile (10 mL) at room temperature under argon atmosphere. The reaction mixture was stirred at room temperature overnight. Solvent was evaporated under reduced pressure, and the crude product was purified using a Teledyne Isco Combiflash Rf purification machine using 0-10% CHCl3/methanol as eluent to provide the desired amides 3-59 in 68-95% yields.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1008-91-9, 1-(Pyridin-4-yl)piperazine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Mathew, Bini; Snowden, Timothy S.; Connelly, Michele C.; Guy, R. Kiplin; Reynolds, Robert C.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 12; (2018); p. 2136 – 2142;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem