As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1000340-35-1, name is 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde, molecular formula is C8H5BrN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 1000340-35-1
Sodium borohydride (0.098 g, 0.0026 mole) was added in portions to a stirred suspension of 4-bromo-lH-pyrrolo [2, 3-b] pyridine-3-carboxaldehyde (0.4 g, 0.0017 mol) in methanol (15 inL) to obtain a clear solution. After completion of reaction, the reaction mixture was concentrated to obtain a residual mass that was diluted with water (25 mL) and extracted with ethyl acetate (25 mL x 3). The organic extracts were combined, dried over anhydrous Na2SC>4 and concentrated under vacuum to obtain the title compound. Yield: 0.35 g; – NMR (DMSO- , 400 MHz) delta ppm: 4.76 – 4.77 (d, J = 4.82 Hz, 2H), 4.86 -(bs, 1H), 7.28 – 7.29 (d, J = 5.04 Hz, 1H), 7.46 – 7.48 (d, J = 8 Hz, 1H), 8.02 – 8.03 (d, J = 5 Hz, 1H), 11.82 (s, 1H); Mass (m/z): 227.0 (M+H)+.
With the rapid development of chemical substances, we look forward to future research findings about 1000340-35-1.
Reference:
Patent; SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; SHINDE, Anil Karbhari; MOHAMMED, Abdul Rasheed; BADANGE, Rajesh Kumar; JAYARAJAN, Pradeep; BHYRAPUNENI, Gopinadh; JASTI, Venkateswarlu; (172 pag.)WO2018/42362; (2018); A1;,
Pyridine – Wikipedia,
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