Application of 1030632-94-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1030632-94-0, name is 5-Ethyl-2-(trifluoromethyl)pyridine, molecular formula is C8H8F3N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 3. Preparation of 5-(1-Bromoethyl)-2-trifluoromethylpyridine N-Bromosuccinimide (1.78 g, 0.01 mol) was added to anhydrous fresh methylene chloride (60 mL) at room temperature under an atmosphere of nitrogen. Once dissolved, the solution was cooled to 0 C. The 5-ethyl-2-trifluoromethyl-pyridine pyridine (1.75 g, 0.01 mol) was dissolved in a small amount of anhydrous methylene chloride and was added via syringe followed by zirconium tetrachloride (117 mg, 0.5 mmol). The ice bath was taken away and the mixture allowed to stir at room temperature overnight. TLC showed complete reaction (9:1, hexane:EtOAc). The reaction mixture was quenched with saturated sodium bicarbonate (25 mL). The organic layer was separated and washed with brine and dried (MgSO4). The residue was purified by column chromatography (1:20, EtOAc:Hex) to give the product, 2.04 g (80%), as a pale yellow liquid; 1H NMR (CDCl3) delta 8.77 (s, 1H), 7.97 (d, 1H), 7.69 (d, 1H), 5.21 (q, 1H), 2.08 (d, 3H)
According to the analysis of related databases, 1030632-94-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Heller, Stephen T.; Ross, Ronald; Irvine, Nicholas M.; Renga, James M.; Zettler, Mark M.; Erndt, Kim E.; US2008/132705; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem