A new synthetic route of 1074-98-2

The chemical industry reduces the impact on the environment during synthesis 1074-98-2, I believe this compound will play a more active role in future production and life.

Related Products of 1074-98-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1074-98-2, name is 3-Methyl-4-nitropyridine 1-oxide, molecular formula is C6H6N2O3, molecular weight is 154.13, as common compound, the synthetic route is as follows.

A suspension of 3-methyl-4-nitropyridine N-oxide (2.0 g, 13 mmol) and palladium hydroxide on carbon (0.4 g) in ethanol (30 mL) was heated to 60 C. Ammonium formate (3.3 g, 52 mmol) was then added portionwise and the mixture heated at 60 C for three hours. The cool reaction mixture was filtered through Arbocel and the filtrate evaporated under reduced pressure to afford the title compound as a colourless oil, 1.81 g. LRMS (APCI+): m/z [M+H]+ 125

The chemical industry reduces the impact on the environment during synthesis 1074-98-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/121094; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem