As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1186647-69-7, name is 4-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine, molecular formula is C6H3ClIN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1186647-69-7
Intermediate 44-Chloro-3-iodo- 1-(4-methoxy-benzyl)~ 1 H-pyrazolo[4, 3-c]pyridine To a mixture of Intermediate 3 (1 g, 3.6 mmol) and KOH (0.3 mg, 5.4 mmol) in DMF (10 ml) at room temperature was added 4-methoxybenzyl chloride (0.5 ml, 3.6 mmol). The resulting mixture was stirred at room temperature for 2.5 h, and then evaporated to dryness. The crude residue was dissolved in EtOAc and washed with water. The organic phase was dried and purified by flash chromatography, eluting with 0 to 30% ethyl acetate/petroleum ether gradient to give a 9:1 mixture of regioisomers as a solid (1.3 g, 93%). Major regioisomer: 1H NMR (400 MHz, DMSO-dB) delta ppm 3.72 (s, 3 H), 5.62 (s, 2 H), 6.85 – 6.94 (m, 2 H), 7.20 – 7.27 (m, 2 H), 7.95 (d, J=6.0 Hz, 1 H), 8.20 (d, J=6.0 Hz, 1 H); m/z (ES+APCI)+: 400 [M + H]+.
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Reference:
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; GENENTECH INC.; CHAN, Bryan; CHEN, Huifen; ESTRADA, Anthony; SHORE, Daniel; SWEENEY, Zachary; McIVER, Edward; WO2012/38743; (2012); A1;,
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