Application of 1207557-36-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1207557-36-5, name is 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine. A new synthetic method of this compound is introduced below.
To a 0C solution of 6- bromo-4-methoxypyrazolo[1,5-a]pyridine (0.75 g, 3.303 mmol) in DMF (33 mL) was slowly added POCl3 (0.92 mL, 9.909 mmol). The reaction was warmed to ambient temperature and stirred for 4 h and then diluted with H2O (30 mL). The resulting suspension was basified to pH 9-10 with 1 M NaOH(aq), then stirred for 1 h and vacuum filtered, then rinsed sequentially with H2O (25 mL) and MTBE (50 mL) to yield the title compound (0.76 g, 90% yield). MS (apci) m/z = 256.9 (M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1207557-36-5, 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine, and friends who are interested can also refer to it.
Reference:
Patent; REYNOLDS, Mark; EARY, Charles Todd; (467 pag.)WO2019/75114; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem