Adding a certain compound to certain chemical reactions, such as: 122306-01-8, (6-Bromopyridin-3-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of (6-Bromopyridin-3-yl)methanol, blongs to pyridine-derivatives compound. Quality Control of (6-Bromopyridin-3-yl)methanol
After dissolving the (6-bromo-3-pyridyl)methanol (45.5 g, 0.242 mol) in dimethylformamide (500 ml),tert-butyl diphenylsilyl chloride (69 ml, 0.266 mol) and imidazole (18 g, 0.264 mol) were added while stirring at room temperature. The mixture was stirred at room temperature for an additional 17 hours, 500 ml of water was added and extraction was performed with diethyl ether (500 ml x 2), and then after washing the combined organic layers with brine (500 ml) and drying over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (light yellow syrup, 76.9 g, 74.3%).1H-NMR(CDCl3)delta(ppm) 1.08(9H,s), 4.71(2H,s), 7.34-7.47(6H,m), 7.52(1H,d,J=8.0Hz), 7.65(4H,d,J=8.0Hz), 7.71(1H,d,J=8.0Hz), 8.29(1H,s).
The synthetic route of 122306-01-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eisai Co., Ltd.; EP1391451; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem