A new synthetic route of 1228631-54-6

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1228631-54-6, 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanol, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1228631-54-6, 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanol, blongs to pyridine-derivatives compound. Safety of 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanol

To a 0 C mixture l-(6-(trifluoromethyl)pyridin-3-yl)ethanol (8.0 mmol) and triphenylphosphine (3.8 g, 14.6 mmol) in THF (55 mL) under N2atmosphere is added perbromomethane (3.8 g,12.2 mmol). After stirring at 0 C for 2 min, the mixture is allowed to warm to room temperature and stirred for 25 min. The precipitate is filtered off through a pad of celite, the solid is washed with cold THF (10 mL). The solution is collected and organic phases combined. The solvent is removed under reduced pressure

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1228631-54-6, 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; SOLVAY SA; BRAUN, Max Josef; (21 pag.)WO2017/198812; (2017); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem