Related Products of 1256823-07-0 ,Some common heterocyclic compound, 1256823-07-0, molecular formula is C7H5BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 3. Preparation of 4-methoxy-5-(4-methyl-1 /-/-imidazol-1 -yl)pyridine-2- carbonitrile (C3). 4-Methyl-1 /-/-imidazole (15 g, 0.18 mol), potassium carbonate (34 g, 0.25 mol) and 18-crown-6 (64 g, 0.24 mol) were combined in acetonitrile (600 mL), and the reaction mixture was heated to 60 C for 2 hours. 5-Bromo-4- methoxypyridine-2-carbonitrile (C2) (25 g, 0.12 mol) was added in one portion, and the reaction was heated to reflux for 18 hours. After being combined with an identical reaction mixture, the reaction was partitioned between water (500 mL) and ethyl acetate (500 mL). The aqueous layer was extracted with ethyl acetate (2 x 300 mL), and the combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated. Purification by chromatography on silica (Gradient: 1 :10 to 1 :2 ethyl acetate: petroleum ether) provided the title product as a white solid. Yield: 8.2 g, 0.038 mol, 16%. NMR (400 MHz, CDCI3) delta 2.30 (d, J=1 Hz, 3H), 4.02 (s, 3H), 6.96-6.97 (m, 1 H), 7.38 (s, 1 H), 7.82 (d, J=1.5 Hz, 1 H), 8.53 (s, 1 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1256823-07-0, 5-Bromo-4-methoxypicolinonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O’DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani; WO2011/48525; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem