Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 128071-98-7, name is 4-Bromo-2-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4-Bromo-2-fluoropyridine
Reaction under inert Ar atmosphere.Intermediate (136) (1 g, 0.00306 mol) was dissolved in TFA (15 ml). The solution was stirred overnight at 1000C. The mixture was cooled and the deep black mixture was concentrated in vacuo. The residue was taken up in ethyl acetate. The organic layer was washed with NaHCO3 (saturated), water and brine, dried (Na2SO4), filtered and the solvent was evaporated (green residue). This green solid was dissolved in dioxane (15 ml) under an inert atmosphere of Ar. 4-Bromo-2-fluoropyridine (0.00306 mol), Cs2CO3 (1.5 g, 1.5 equiv.), Xantphos (0.09 g) and Pd2(dba)3 (0.08 g) were added. The reaction was degassed for 15 minutes and was then heated for 30 minutes at 800C. The cooled mixture was concentrated in vacuo and the resulting thick brown oil was taken up in chloroform. The organic layer was washed with NaHCO3 (saturated), water and brine, dried (Na2SO4), filtered and the solvent was evaporated to yield a brown solid. This solid was purified by column chromatography over silica gel (eluent: hexane/ethyl acetate 1/1). The desired fractions were collected and the solvent was evaporated, yielding 0.642 g of intermediate (137).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 128071-98-7, 4-Bromo-2-fluoropyridine.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2008/3665; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem