A new synthetic route of 13472-56-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13472-56-5, 2-Methoxy-5-methylpyridine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 13472-56-5, Adding some certain compound to certain chemical reactions, such as: 13472-56-5, name is 2-Methoxy-5-methylpyridine,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13472-56-5.

Add 6-methoxy-3-methylpyridine and dibenzoyl peroxide to the dichloromethane solvent, turn on the stirring, reduce the temperature in the ice-water bath to 20-30 C, and add the bromine in batches to the reaction solution. , Maintain the internal temperature below 40 C, add it, heat to reflux, and react for 24 hours. The specific reaction equation is as follows:The post-treatment process is: the reaction solution is cooled to 25-30 C, filtered under reduced pressure, and the filter cake is rinsed once with dichloromethane; the filtrate is washed three times with water; concentrated under reduced pressure until no liquid drips; petroleum ether is added to the concentrated solution, The amount of petroleum ether is 3.0-4.0 times that of 6-methoxy-3-methylpyridine, beaten at 25-30 C for 30min .; filtered under reduced pressure, and the cake is dried under vacuum at 40-50 C to obtain 5- (dibromomethyl) Group) -2-methoxypyridine, yield 83.8%, purity was measured by HPLC method, and purity was 99%.Among them, the amount of methylene chloride is 4.0-5.0 times that of 6-methoxy-3-methylpyridineThe molar ratio of 6-methoxy-3-methylpyridine to the catalyst was 1: 0.01.The molar ratio of 6-methoxy-3-methylpyridine to bromine is 1: 2.6.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13472-56-5, 2-Methoxy-5-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing Habo Pharmaceutical Technology Co., Ltd.; Zhao Xiaolin; Cui Jiayi; Wang Jinzhu; Zhao Bing; Ai Yangbao; (10 pag.)CN110878043; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem