Electric Literature of 13958-86-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13958-86-6, name is 5-Methylpyridine-3,4-diamine. A new synthetic method of this compound is introduced below.
3,4-diamino-5-methylpyridine (413 mg, 3.35 mmol)Mixed with 20 ml of dimethyl oxalate,Warm to reflux and stir for 3-4 hours.After the reaction solution was cooled, the resulting solid was filtered off.The solid was dispersed in 15 ml of N,N-dimethylformamide.Add 1 g of activated carbon, raise the temperature to reflux, and filter it hot after 1 hour.Add 1 ml of water to the filtrate.Allow to stand for 1 hour,The precipitated white solid is filtered,Washed with water, washed with 95% ethanol,Ethyl acetate wash to give 8-methyl-6-azaquinoxaline-2,3-dione white solid(434 mg, yield 73.1%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13958-86-6, 5-Methylpyridine-3,4-diamine, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Jiao Tong University; Wang Yongxiang; Fu Lei; Xie Dongsheng; Lu Jun; (37 pag.)CN103435561; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem