In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 139585-48-1, name is 2-Chloro-5-methoxypyridine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Chloro-5-methoxypyridine
To a 14 mL test tube equipped with a stir bar was added (S)-(5-(1-(tert-butoxy)-2-isopropoxy-2-oxoethyl)-4-(4,4-dimethylpiperidin- 1 -yl)-6-methylpyridin-3 -yl)boronic acid(105 mg, 0.250 mmol), SPhos-Pd-G3 (9.73 mg, 0.0 12 mmol), tribasic potassium phosphate (477 mg, 2.248 mmol) and 2-chloro-5-methoxypyridine (35.9 mg, 0.250 mmol) . The flask was sealed with a rubber septum, then was placed under N2 atm (vac/fill x 3). To the flask was added degassed (N2 bubbling for 5 mm) dioxane (937 .il) and water (312 .il) . The test tube was placed in a 60 C heating block with stirring (t=0). The reaction was stirred for 3 hours. The reaction was cooled to RT and diluted withwater and EtOAc. The organic layer was washed with brine, collected, dried over MgSO4, filtered and hte volatiles evaporated to afford the cmde product. The crude product was purified on silica gel (24 g column, 20-100% EtOAc:Hex) to afford the product isopropyl (S)-2-(tert-butoxy)-2-(4?-(4,4-dimethylpiperidin- 1 -yl)-5 -methoxy-6?-methyl-[2,3 bipyridinj-5?-yl)acetate (22 mg, 0.045 mmol, 18.21 % yield) as a brown oil. ESI-MS(+)m/z = 484.3 (M+1).
The synthetic route of 139585-48-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
Pyridine – Wikipedia,
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