Related Products of 14237-71-9 , The common heterocyclic compound, 14237-71-9, name is 2-Chloro-4,6-dimethylnicotinonitrile, molecular formula is C8H7ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A mixture of the corresponding chloroderivatives (pyridine, pyridazine, coumarin, and nicotinic acid)(10 mmol), selenium metal (1 g, 12 mmol) and sodium borohydride (1.2 g, 32 mmol) in EtOH (50 mL) were stirred till colorless. After that, DMF (20 mL) was added then deep red browncolor appeared. An additional selenium metal (1 g, 12 mmol)was added with EtOH (5 mL). The reaction mixture was reuxedfor 3 hrs., then cooled and poured in ice/HCl. The solid thus separated out was fltered, dried, and recrystallized from ethanol.2,2-Bis(3-cyano-4,6-dimethyl)dipyridyldiselenide (5a): mp244-245C. Data is in agreement with literature survey.20
The synthetic route of 14237-71-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Abdel-Hafez, Shams H.; Abdelwahab, Ahmed B.; Kirsch, Gilbert; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 192; 10; (2017); p. 1114 – 1118;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem