With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1594-57-6, name is N-Hydroxyisonicotinimidamide, molecular formula is C6H7N3O, molecular weight is 137.14, as common compound, the synthetic route is as follows.category: pyridine-derivatives
Example 1: 4- (3-Pyridin-4-yl- [1, 2,4] oxadiazol-5-ylmethoxy) piperidine-1-carboxylic acid tert- butyl ester A stirred solution of triethylamine (123mul, 0. 87mmol) and 4-carboxymethoxypiperidine- 1-carboxylic acid tert-butyl ester (Preparation 1,227mg, 0. 87mmo1) in toluene (10ml) was treated with isobutylchloroformate (113mul, 0. 87mmol). After 20min, activated powdered 3A molecular sieves (0.7g) andN-hydroxyisonicotinamidine (lOOmg, 0. 73mmol) were added and the mixture heated under reflux for 18h. On cooling, the mixture was filtered through celite, the solvent removed in vacuo and the residue purified by flash chromatography (IH-EtOAc, 7: 13) to afford the title compound: RT = 3. 29min ; m/z (ES+) 361.3 [M+H] + ; OH (CDC13) 1.40 (9H, s), 1.55-1. 63 (2H, m), 1.80-1. 92 (2H, m), 3.05-3. 15 (2H, m), 3.64-3. 79 (3H, m), 4.80 (2H, s), 7.90 (2H, d), 8.75 (2H, d).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1594-57-6, N-Hydroxyisonicotinimidamide, and friends who are interested can also refer to it.
Reference:
Patent; PROSIDION LIMITED; WO2005/61489; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem