1604-14-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1604-14-4, name is 2,6-Dichloro-isonicotinic acid ethyl ester. A new synthetic method of this compound is introduced below.
A solution of phenylboronic acid (915 mg, 7.50 mmol) in methanol (15 mL) was added to a stirred solution of ethyl-2,6- dichloro-isonicotinate (750 mg, 3.41 mmol) and tetrakis- (TRIPHENYLPHOSPHINE)-PALLADIUM (0) (197 mg, 5 mol%) in toluene (60 mL). 2N sodium carbonate (3.41 mL, 6.82 mmol) was added and the reaction was heated to 90C (oil bath temp. ) for 2-3 hrs until complete (TLC control). The reaction mixture was cooled to room temperature and partitioned between water and diethyl ether. The phases were separated, the aqueous phase being further extracted with diethyl ether (3 x 30 mL). The combined extract was washed with water and brine. The ethereal solution was dried over anhydrous MGS04, filtered and concentrated in vacuo to yield the title compound as a white solid (941 mg, 91 %) ; Rf: 0.5 (30% ethyl acetate in heptane); 1H NMR (CDC13, 300 MHz) 6 8.18 (2H, s, ArH), 8.12 (4H, m, ArH), 7.42 (6H, m, ArH), 4.38 (2H, q, J = 7 Hz, CH20), 1.39 (2H, t, J = 7HZ, CH3).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1604-14-4, 2,6-Dichloro-isonicotinic acid ethyl ester, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE INSTITUTE OF PHARMACEUTICAL DISCOVERY, LLC; WO2004/99192; (2004); A2;,
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