Synthetic Route of 166266-19-9, Adding some certain compound to certain chemical reactions, such as: 166266-19-9, name is 5-Iodo-3-methylpyridin-2-amine,molecular formula is C6H7IN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 166266-19-9.
Production Example 4: Production of 2-amino-3-methyl-6-pentafluoroethylpyridine (Compound No. IV-1) To 20 ml of dimethyl sulfoxide were added 2.34 g (0.01 mol) of 2-amino-5-iodo-3-methylpyridine, 2.5 g of powdered metallic copper and 3.7 g (0.015 mol) of iodopentafluorethane. The mixture was kept at 110C and vigorously stirred for 6 hours. After cooling the reaction mixture to room temperature, the mixture was poured into 500 ml of ice water and thoroughly stirred. The insoluble matter was filtered off, and the objective product was extracted from the filtrate with 300 ml of ethyl acetate. The extract solution was washedwith water, dried on anhydrous sodium sulfate, and concentrated under reduced pressure. Purification of the residue by column chromatography using 3/7 mixture of ethyl acetate and hexane as an eluent gave 1.1 g of the objective product (yield 20%). 1H-NMR [delta (CDCl3)]: 2.17 (s,3H), 4.82 (br,2H), 7.42 (d,1H), 8.16 (s,1H),
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 166266-19-9, 5-Iodo-3-methylpyridin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Nihon Nohyaku Co., Ltd.; EP1193254; (2002); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem