Synthetic Route of 17368-12-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 17368-12-6 as follows.
A solution of 2-chioropyridin-4-ol (1.0 g, 7.72 mmoi) in DMF (20 rnL) was treated wtih i,i-difluoro-2-iodoethane (1.14 mL, 1.92 mmol) and K2C03 (1.6 g, 11.58 mmol)and heated at 60 C overnight, The reaction was diluted with EtOAc and washed with saturated, aqu. NaHCO3, then with brine. The organics were dried over Na2SO4, filtered,and concentrated, The crude material was purified by chromatography on silica (0-30% EtOAc in hexanes) to give the title compound as an oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17368-12-6, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; LIVERTON, Nigel; LUO, Yunfu; SKUDLAREK, Jason; (79 pag.)WO2016/95204; (2016); A1;,
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