A new synthetic route of 19524-06-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19524-06-2, 4-Bromopyridine hydrochloride, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 19524-06-2, 4-Bromopyridine hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H5BrClN, blongs to pyridine-derivatives compound. COA of Formula: C5H5BrClN

A solution of 4-bromo-pyridine hydrochloride (25 g, 128 mmol) in dichloromethane (250 mL) was treated with potassium carbonate (21.25 g, 153 mmol) and the mixture was stirred for 2 hours, followed by addition of m-chloroperbezoic acid (44 g, 256 mmol). The mixture was stirred at room temperature for 16 hours, solid precipitated out, filtered and washed with ethyl acetate (2*200 mL). The filtrate was concentrated to give solid material which was washed with ether and hexane (3*30 mL, 1:1). The solid (20 g, 90percent) obtained was used as such for next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19524-06-2, 4-Bromopyridine hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; Daiichi Sankyo Company, Limited; Verma, Ashwani Kumar; Nagaswamy, Kumaragurubaran; Sharma, Lalima; Ghosh, Soma; Kale, Balkrishna Ramchandra; Mondal, Aniruddha; Srivastava, Punit Kumar; Dastidar, Sunanda Ghosh; Momin, Rijwan Jaffer; Wagh, Pradip Balu; Pansare, Sonali Nanasaheb; Markad, Pramod Raosaheb; Khairnar, Yogesh Balasaheb; Miyauchi, Rie; Murata, Takeshi; Ishizaki, Masayuki; Nagamochi, Masatoshi; Iimura, Shin; US2014/155398; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem