A new synthetic route of 197376-47-9

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 197376-47-9, Ethyl 6-Chloropyridine-3-acetate, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 197376-47-9 ,Some common heterocyclic compound, 197376-47-9, molecular formula is C9H10ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Reference Example 74 ethyl [6-(methylsulfanyl)pyridin-3-yl]acetate To a solution of ethyl (6-chloropyridin-3-yl)acetate (10.7 g) in N,N-dimethylformamide (100 mL) was added sodium methanethiolate (11.3 g), and the mixture was stirred at room temperature for 23 hr. The reaction mixture was diluted with ethyl acetate, washed successively with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane =5:95 – 50:50, volume ratio) to give the title compound (4.55 g, yield 40%) as a colorless oil. MS:212(MH+). _

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 197376-47-9, Ethyl 6-Chloropyridine-3-acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2149550; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem