Application of 116855-08-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.116855-08-4, name is 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid, molecular formula is C7H5N3O2, molecular weight is 163.13, as common compound, the synthetic route is as follows.
Step 5[00179] To a solution of lH-pyrazole[3,4-£]pyridine-3-carboxylic acid (V) (0.39 g, 2.4 mmol) in dry MeOH (10 mL) was added concentrated H2S04 (4 drops) and refluxed for 6 h under nitrogen. The solution was cooled and the solvent was evaporated under vacuum. The residue was partitioned between DCM and saturated NaHC03 solution. The organic layer was separated, dried over MgS04, filtered and concentrated under reduced pressure. The crude product was purified on a flash silica gel column (100% DCM?100:3 DCM:MeOH) to produce methyl lH-pyrazolo[3,4-6]pyridine-3- carboxylate (VI) as a white solid (382 mg, 2.16 mmol, 90% yield). 1H NMR (CDC13) delta ppm 4.08 (s, 3 H), 7.38 (m, 1 H), 8.63 (dd, J=8.10, 1.51 Hz, 1 H), 8.72 (dd, J=4.62, 1.41 Hz, 1 H); ESIMS found for C8H7N302 mlz 178.2 (M+H).
Statistics shows that 116855-08-4 is playing an increasingly important role. we look forward to future research findings about 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid.
Reference:
Patent; EPITHERIX, LLC; HOOD, John; KC, Sunil Kumar; WALLACE, David Mark; WO2011/84486; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem