Adding a certain compound to certain chemical reactions, such as: 24016-03-3, 2-Amino-3-benzyloxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Amino-3-benzyloxypyridine, blongs to pyridine-derivatives compound. Safety of 2-Amino-3-benzyloxypyridine
Step A: Preparation of 3-(benzyloxy)-5-bromopyridin-2-arnine:; 3-(Benzyloxy)pyridin-2-amine (25.0 g, 124.9 mmol) was added to acetonitrile (300 mL) and cooled to 0 0C. l-Bromopyrrolidine-2,5-dione (22.22 g, 124.9 mmol) was added portionwise and the reaction mixture was stirred for 15 minutes, then concentrated to dryness. The residue was dissolved in EtOAc and partitioned with water. The organic layer was washed twice with saturated sodium bicarbonate and once with brine. Activated charcoal was added to the organic layer, and the organic layer was warmed to reflux, then cooled, filtered through a plug of celite, and concentrated to give 9.4 g of the title compound. The celite and charcoal were resupended in EtOAc and filtered through a celite plug to give an additional 3.6 g of the title compound, to provide a total of 12.0 g (34.3% yield). 1H NMR (CDCl3) delta 7.74 (d, IH), 7.41 (m, 5H), 7.08 (d, IH), 5.04 (s, 2H), 4.74 (bs, 2H). Mass spectrum (apci) m/z = 279.1 (M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,24016-03-3, 2-Amino-3-benzyloxypyridine, and friends who are interested can also refer to it.
Reference:
Patent; ARRAY BIOPHARMA INC.; AICHER, Thomas Daniel; LEE, Wai-Man; HINKLIN, Ronald Jay; CHICARELLI, Mark Joseph; BOYD, Steven Armen; CONDROSKI, Kevin Ronald; WO2007/53345; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem