The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 175205-81-9, name is 2-Bromo-4-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Bromo-4-(trifluoromethyl)pyridine
General procedure: To a solution of 4-amino-l-((tr<3i)-3-(benzyloxy)cyclobutyl)-lH-pyrazolo[3,4- d]pyrimidin-3-ol (3) (200 mg, 642 mumol,, 1 eq) in DMSO (10 mL) was added 2-bromo-4- (trifluoromethyl)pyridine (IB) (233 mg, 1.28 mmol, 2 eq) and IGCO3 (178 mg, 1.28 mmol, 2 eq) and the mixture was stirred at 125°C for about 3 h. The mixture was filtered and the filtrate was purified by prep-HPLC (TFA condition) to give l -((trans)-3- (benzyloxy)cyclobutyl)-3-((4-(trifluoromethyl)pyridin-2-yl)oxy)-l H-pyrazolo[3,4- d]pyrimidin-4-amlne (4) (150 mg, 263 mumol, 40.9percent yield) as a white solid.
With the rapid development of chemical substances, we look forward to future research findings about 175205-81-9.
Reference:
Patent; VYERA PHARMACEUTICALS, LLC; WASHINGTON UNIVERSITY; HOPPER, Allen, T.; SIBLEY, L., David; JANETKA, James, W.; HELANDER, Jon; (149 pag.)WO2019/36001; (2019); A1;,
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