A new synthetic route of 2-Bromo-5-chloro-3-nitropyridine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75806-86-9, its application will become more common.

Related Products of 75806-86-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 75806-86-9 as follows.

Example 3: General procedure A: Synthesis of 5-chloro-3-nitro-2-aryloxy- pyridines and 5-chloro-3-nitro-2-arylsulfanyl-pyridines; [00383] A mixture of the appropriate hydroxyaryl or thioaryl (1.3 equiv), 2- bromo-5-chloro-3-nitro-pyridine (1 equiv) and K2CO3 (1.5 equiv) in DMF was heated at 80 C overnight. The resulting mixture was cooled to room temperature, and diluted with water and CH2CI2. The biphasic mixture was separated and the aqueous portion was extracted with CH2CI2. The combined extracts were washed with saturated aqueous NaHCO3, brine and dried (Na2SO4). It was then filtered and filtrate was concentrated under reduced EPO pressure and the product was purified by flash column chromatography on silica gel to provide desired product.; Example 4: 5-Chloro-3-nitro-2-phenoxy-pyridine; [00384] This compound was prepared according to the general procedure described above using 2-bromo-5-chloro-3-nitro-pyridine (500 mg, 2.11 mmol), phenol (258 mg, 2.75 mmol), K2CO3 (437 mg, 3.16 mmol) and DMF (2 mL). MS m/z : 250.4 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75806-86-9, its application will become more common.

Reference:
Patent; CHEMOCENTRYX, INC.; WO2006/76644; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem