Electric Literature of 1204296-03-6 ,Some common heterocyclic compound, 1204296-03-6, molecular formula is C6H4ClF2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-Chloro-4-(difluoromethyl)pyridine (2.0 g, 12 mmol) and (R)-3-methylbutan-2-amine (4.3 g, 49 mmol) were added to a 30 mL microwave tube. The resultant mixture was stirred while heating at 180 C. for 16 hours and at 200 C. for another 16 hours before cooling to room temperature and concentrating to dryness under reduced pressure to give the crude product, which was purified by FCC (0-10% ethyl acetate/petroleum ether) to afford the title compound as a yellow oil
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1204296-03-6, its application will become more common.
Reference:
Patent; Janssen Pharmaceutica NV; Goldberg, Steven; McClure, Kelly; Tanis, Virginia M.; Fennema, Elizabeth G.; Lebsack, Alec D.; Martin, Connor L.; Venkatesan, Hariharan; Xue, Xiaohua; Woods, Craig R.; (531 pag.)US2017/313691; (2017); A1;,
Pyridine – Wikipedia,
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