Electric Literature of 17228-64-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17228-64-7, name is 2-Chloro-6-methoxypyridine, molecular formula is C6H6ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To the solution of Compound 57 (10.0 g, 69.6 mmol, 1.00 eq) in THF (200 mL) andNMP (20.0 mL) was added Fe(acac)3 (1.23 g, 3.48 mmol, 0.05 eq). Then i-PrMgC1 (2 M, 41.79 mL, 1.20 eq) was added dropwise at -30 C within 30 mm. The mixture was stirred at 0 C for 1 h. The reaction mixture was quenched with saturated aqueous NH4C1 (80 mL) at 0 C. Then the two phases were separated and the aqueous phase was extracted with methyl t-butyl ether (80 mL). The combined organic phases were washed with water (4 x 50 mL). Then the organic phase was dried over anhydrous Na2504, filtered and concentrated to give compound 58 (7.10 g, 46.9 mmol, 67% yield) as a yellow liquid which was used for the next step without purification.?H NMR (400MHz, Chloroform-d) oe = 7.48 (t, J 7.7 Hz, 1H), 6.72 (d, J 7.1 Hz, 1H), 6.54 (d, J 7.9 Hz, 1H), 3.93 (s, 3H), 2.95 (td, J 6.8, 13.7 Hz, 1H), 1.28 (d, J= 7.1 Hz, 6H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17228-64-7, 2-Chloro-6-methoxypyridine.
Reference:
Patent; AFFERENT PHARMACEUTICALS INC.; HAWLEY, Ronald Charles; IBRAHIM, Prabha; FORD, Anthony, P.; GEVER, Joel, R.; (171 pag.)WO2017/160569; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem